Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hypothermal perfusion: protection or damage?].

N E Zatsepina, R N Korotkina, L S Smirnov

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |July 4, 2002
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Aorto-esophago-bronchial and aorto-pulmonary fistulas in a patient with aortic aneurysm].

    Khirurgiia·2019
    Same author

    [Cardiopulmonary bypass and circulatory support in Petrovsky Russian Research Center for Surgery].

    Khirurgiia·2018
    Same author

    [Cardiopulmonary bypass in thoracic surgery].

    Khirurgiia·2017
    Same author

    [ASSESSMENT OF LIVER FUNCTION WITH TRANSESOPHAGEAL ECHOCARDIOGRAPHY HEART SURGERY WITH CARDIOPULMONARY BYPASS].

    Anesteziologiia i reanimatologiia·2016
    Same author

    [GAS MICROEMBOLISM DURING EXTRACORPOREAL CIRCULATION].

    Anesteziologiia i reanimatologiia·2016
    Same author

    [ANAESTHETIC MANAGEMENT OF RECONSTRUCTIVE SURGERY ON THE AORTIC ARCH: THE NUANCES OF ORGAN PROTECTION].

    Anesteziologiia i reanimatologiia·2016

    Superficial hypothermia during open heart surgery minimizes myoglobin release and preserves platelet function. Deep hypothermia, especially at 14°C, significantly increases myoglobinemia, potentially impairing heart contractility.

    Area of Science:

    • Cardiovascular Surgery
    • Physiology
    • Biochemistry

    Context:

    • Open heart and great vessel operations require cardiopulmonary bypass.
    • Hypothermia is used to reduce metabolic demand during cardiac surgery.
    • The study investigates the impact of varying hypothermia levels on myoglobin and platelet markers.

    Purpose:

    • To evaluate the effect of different cardiopulmonary bypass temperatures on blood myoglobin levels and platelet count/activity.
    • To identify optimal temperature ranges for minimizing myoglobin release and preserving platelet function during cardiac surgery.

    Summary:

    • Ninety-six patients undergoing cardiac surgery were analyzed across four hypothermia groups (30-32°C, 26-29°C, 23-26°C, 12-14°C).
    • Minimal myoglobin release and optimal platelet counts/activity were observed with superficial hypothermia (30-32°C) and moderate PaO2.

    Related Experiment Videos

  • Deep hypothermia (12-14°C) led to critical myoglobinemia (over 30x baseline), while increased PaO2 generally elevated myoglobin levels.

    • Impact:

    • Myoglobin release from the myocardium can lead to impaired blood supply and reduced contractility.
    • Significant platelet loss increases the risk of postoperative bleeding (hemorrhagic diathesis).
    • Findings suggest careful management of hypothermia and PaO2 is crucial for improving outcomes in cardiac surgery.