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Nuclear morphometric analysis of T2 lesions of the rectum--a simple, reproducible method for predicting malignancy
Fumihiko Ishikawa1, Norio Saito, Keiji Koda
1Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba City, Japan.
Background:
Using computerized nuclear morphometry, we searched for common, objective parameters for use in predicting potential malignancy of primary T2 tumors of the rectum.
Methods:
In 119 surgically resected T2 rectal cancers, the following parameters of the cancer cell nuclei were microscopically measured: mean nuclear area (NA), mean perimeter (PM), largest-to-smallest diameter ratios (LS), circularity factor (CF), and coefficient of variation of nuclear area (NACV). The calculated parameters were retrospectively analyzed and compared with patients' outcome.
Results:
NA, PM, and NACV correlated with recurrence. NA and NACV were significantly associated with disease-free survival. High NACV correlated with lymph node metastasis. In node-negative cases, high NACV correlated with recurrence and tended to be associated with poor prognosis.
Conclusions:
These findings suggest that computerized morphometry is useful for predicting malignancy potential of T2 lesions of the rectum.
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