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Published on: December 15, 2011
Autoantibodies to transducin in a patient with melanoma-associated retinopathy
Michael J Potter1, Grazyna Adamus, Shelagh M Szabo
1Department of Ophthalmology, University of British Columbia, Vancouver, Canada. mpotter@interchange.ubc.ca
Purpose:
To report novel immunoreactivity in a patient with melanoma-associated retinopathy.
Design:
Retrospective case report and experimental study.
Methods:
A 32-year-old woman with a history of metastatic melanoma presented with bilateral decreased visual acuity. Electroretinography, Goldmann perimetry, immunohistochemistry, and Western blotting of her serum were performed.
Results:
Electroretinography showed a "negative" B-wave. Paracentral and central scotomas were observed on Goldmann perimetry. Antibodies to a retinal transducin were demonstrated by Western blotting. No immunoreactivity to retinal bipolar cells was detected by immunohistochemistry.
Conclusion:
Melanoma-associated retinopathy can be related to a variety of antiretinal antibodies. Recognition of transducin, a novel melanoma-associated retinopathy antigen, may be important for identifying and treating patients with night blindness and melanoma.
