Related Experiment Video
Updated: Sep 30, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Methodological aspects of comparative research in the epidemiology of Alzheimer disease
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Abstract:
In recent years, major advances have been made in the investigation of the incidence and prevalence of Alzheimer disease in diverse social and cultural settings. Examples of issues being addressed are the methods used to estimate incidence and prevalence, the procedures for data collection and its harmonization, the definitions of numerator (cases) and denominator (population at risk), and the modeling of cognitive decline. This type of research will eventually lead to a better understanding of how protective and modifiable risk factors interact with the genotype to produce this disease.
Related Concept Videos
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Introduction to Epidemiology
Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Comparing the Survival Analysis of Two or More Groups
Bias in Epidemiological Studies
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...