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Parotid gland function and dentin apposition in rat molars.
J Leonora1, L Tjäderhane, J-M Tieche
1Department of Physiology/Pharmacology, Risley Hall, School of Medicine, Loma Linda University, CA 92350, USA. Jleonora@som.llu.edu
Journal of Dental Research
|July 5, 2002
Summary
A high-sucrose diet and parotid gland removal both impair dentin formation in rat molars. Parotid gland function positively influences dentin apposition, suggesting its crucial role in tooth development.
Area of Science:
- Oral biology
- Dental research
- Physiology
Background:
- Established down-regulating effect of sucrose-rich diets on primary dentinogenesis in rat molars.
- Observed negative impact of high-sucrose diets on parotid gland function, affecting intradentinal solute movement.
Purpose of the Study:
- To investigate the potential role of parotid gland function(s) in regulating dentinogenesis.
- To assess the impact of diet composition and salivary gland removal on dentin apposition.
Main Methods:
- Measurement of dentin apposition in rat molars using planimetry on sagittal sections.
- Experimental variables included standard vs. high-sucrose diets, parotidectomy, submandibular/sublingual gland removal, and diet form (powder/pellet).
Main Results:
- High-sucrose diet and parotidectomy significantly depressed dentin apposition.
- Combined high-sucrose diet and parotidectomy resulted in a further decrease in dentin apposition.
- Removal of submandibular/sublingual glands or changes in diet consistency did not significantly affect dentin apposition.
Conclusions:
- Parotid glands exert a positive influence on dentin apposition in rat molars.
- Parotid gland function is a significant factor in regulating dentinogenesis, independent of diet consistency or submandibular/sublingual gland activity.