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Cutting edge: CCR7+ and CCR7- memory T cells do not differ in immediate effector cell function.

Heike Unsoeld1, Stefan Krautwald, David Voehringer

  • 1Department of Immunology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany.

Journal of Immunology (Baltimore, Md. : 1950)
|July 5, 2002
PubMed
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This study investigated the role of chemokine receptor CCR7 in T cell function. Results show that CCR7(+) and CCR7(-) T cells exhibit similar effector functions, challenging existing theories.

Area of Science:

  • Immunology
  • Cell Biology
  • T cell immunology

Background:

  • The chemokine receptor CCR7 (C-C chemokine receptor type 7) is proposed to distinguish between nonpolarized central and polarized effector memory T cells.
  • This distinction is based on CCR7 cell surface expression levels.

Purpose of the Study:

  • To test the hypothesis that CCR7 expression defines functional differences in T cells.
  • To investigate the effector functions of CCR7(+) and CCR7(-) T cell populations in vivo.

Main Methods:

  • Utilized P14 and SMARTA TCR-transgenic (tg) mouse models specific for lymphocytic choriomeningitis virus (LCMV) glycoprotein.
  • Monitored CCR7 expression using a CC chemokine ligand 19-Ig fusion protein.
  • Assessed IFN-gamma production and lytic activity of isolated T cell populations.

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Main Results:

  • CC chemokine ligand 19-Ig staining successfully separated T cells into CCR7(+) and CCR7(-) populations.
  • Both CCR7(+) and CCR7(-) T cell populations produced comparable amounts of IFN-gamma upon antigen stimulation.
  • CCR7(+) and CCR7(-) CD8 T cells displayed similar cytotoxic activity against target cells.

Conclusions:

  • The findings question the established concept that CCR7 expression dictates differential effector functions in memory T cells.
  • CCR7's role in defining functional T cell subsets may need re-evaluation based on these results.