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Related Experiment Videos

Estrous-cycle-dependent variation in orthodontic tooth movement.

N Haruyama1, K Igarashi, S Saeki

  • 1Division of Orthodontics, Department of Life-Long Oral Health Science, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

Journal of Dental Research
|July 5, 2002
PubMed
Summary

Tooth movement during orthodontic treatment varies with the female rat

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Area of Science:

  • Reproductive Endocrinology
  • Orthodontics
  • Bone Physiology

Background:

  • Sex hormones, particularly estradiol, are crucial for maintaining bone metabolism.
  • Estrogen levels fluctuate significantly throughout the estrous cycle in female mammals.
  • Understanding hormonal influences is key to optimizing orthodontic treatment outcomes.

Purpose of the Study:

  • To investigate estrous cycle-dependent variations in orthodontic tooth movement.
  • To elucidate the underlying mechanisms, specifically the role of estradiol.

Main Methods:

  • Female Wistar rats were subjected to controlled orthodontic force application timed to specific estrous cycle phases.
  • Tooth movement was quantified and correlated with serum estradiol levels.
  • Bone resorption markers, including TRAP activity and pyridinoline, were measured.

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Main Results:

  • Tooth movement was approximately 33% greater when orthodontic force was applied during estrus compared to pro-estrus (p < 0.05).
  • Serum estradiol levels peaked during pro-estrus and were lowest during estrus, showing an inverse relationship with tooth movement.
  • Estradiol levels negatively correlated with serum TRAP activity (r = -0.42, p < 0.05) and pyridinoline (r = -0.59, p < 0.001), indicating reduced bone resorption at higher estradiol levels.

Conclusions:

  • Estrous cycle phase significantly influences the rate of orthodontic tooth movement in female rats.
  • Cyclic variations in estradiol levels, impacting bone resorption, are associated with these observed differences in tooth movement.
  • These findings highlight the importance of considering hormonal fluctuations in orthodontic treatment planning.