History of the nephron

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Updated: Sep 30, 2026

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method
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Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Published on: May 22, 2019

Antonio Mezzogiorno1, Vincenzo Mezzogiorno, Vincenzo Esposito

  • 1II Università degli Studi di Napoli, Faculty of Medicine and Surgery, Instiute of Human Anatomy, Via Luciano Armanni 5, I-80138 Naples, Italy.

American Journal of Nephrology
|July 5, 2002
PubMed

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Filtration and Urine Formation

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Formation of Concentrated Urine

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Formation of Dilute Urine

The formation of dilute urine is a critical renal adaptation that maintains fluid balance, particularly during periods of high fluid intake. This process primarily involves the juxtamedullary nephrons. By adjusting the permeability of water and ions in response to physiological conditions, the kidneys can either conserve or excrete water, resulting in concentrated or dilute urine.
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