Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A paradigm for quantifying ventricular contraction.

Joseph L Palladino1, Abraham Noordergraaf

  • 1Department of Engineering, Trinity College, Hartford, CT, USA.

Cellular & Molecular Biology Letters
|July 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling the Frank-Starling Mechanism at the Cardiac Muscle and Ventricle Levels.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Canine Smooth Muscle Contraction Model.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2022
Same author

Modeling Mouse Soleus Muscle Contraction.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2020
Same author

Functional Requirements of a Mathematical Model of Muscle Contraction.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2020
Same author

Modeling muscle's nonlinear viscoelastic dynamics.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2015
Same author

What should determine loop time during CPR: a generic algorithm or the patient's initial rhythm?

Resuscitation·2014

This study presents a new model for the left ventricle, viewing it as a pressure generator. It separates isovolumic and ejecting properties for a clearer understanding of heart function.

Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering
  • Cardiac Mechanics

Background:

  • The left ventricle's function as a pressure generator is complex, influenced by time, volume, and flow.
  • Existing models often integrate isovolumic and ejecting phases, complicating analysis.
  • Understanding ventricular-vascular coupling is crucial for diagnosing cardiac conditions.

Discussion:

  • This research introduces a novel analytical function to model left ventricular pressure generation.
  • The model uniquely separates isovolumic pressure measurements from the effects of ejection.
  • It accounts for the 'ejection effect,' a pressure adjustment during ventricular outflow.

Key Insights:

  • A new paradigm separates isovolumic and ejecting ventricular properties.

Related Experiment Videos

  • The model describes pressure generation and outflow across diverse contractile and vascular states.
  • This approach enhances the understanding of ventricular mechanics and its interaction with the vasculature.

    • Outlook:

    • Further validation of the analytical function across a broader range of physiological and pathological conditions.
    • Potential applications in developing advanced diagnostic tools for heart failure.
    • Integration of this model into computational simulations for personalized cardiac treatment strategies.