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Synthesis and applications of end-labeled neoglycopolymers
Robert M Owen1, Jason E Gestwicki, Travis Young
1Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Organic Letters
|July 6, 2002
Abstract:
[reaction: see text] Neoglycopolymers that vary in length and contain a single fluorescent reporter group were synthesized using ring-opening metathesis polymerization (ROMP). The utility of these materials is demonstrated by the development of a cellular binding assay for L-selectin, a cell surface protein that plays a role in inflammation. The data reveal that these multivalent ligands interact with multiple copies of L-selectin.