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[Dnitrophenol--a dangerous doping agent].

Paal Sand1, Steinar Madsen

  • 1Humana Medisinske Senter Postboks 63 1300 Sandvika.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|July 9, 2002
PubMed
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Bodybuilders using dinitrophenol for fat loss experienced central thyroid dysfunction. This dangerous drug can cause severe metabolic issues, including potentially fatal hyperpyrexia, and its use should be avoided.

Area of Science:

  • Endocrinology
  • Toxicology
  • Sports Medicine

Background:

  • Bodybuilders frequently use performance-enhancing drugs, including anabolic steroids, growth hormone, and insulin.
  • Less common and potentially dangerous compounds are also utilized for physique enhancement.

Observation:

  • Two active male bodybuilders presented with lassitude and malaise.
  • Clinical and laboratory evaluations were performed to identify the cause of their symptoms.

Findings:

  • Laboratory results indicated significantly low serum levels of free thyroxine and thyroid-stimulating hormone (TSH), suggesting central hypothyroidism.
  • Both individuals admitted to using dinitrophenol (DNP) at approximately 5 mg/kg bodyweight/day for fat reduction prior to bodybuilding competitions.

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Implications:

  • Dinitrophenol (DNP) is a toxic compound with severe metabolic consequences, including the risk of hyperpyrexia and death.
  • Healthcare providers should be aware of DNP use among bodybuilders and its potential health risks.
  • The use of DNP for non-medical purposes, particularly in bodybuilding, should be strongly discouraged due to its toxicity.