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Growth hormone signal transduction.
Graciela Piwien-Pilipuk1, Jeffrey S Huo, Jessica Schwartz
1Department of Physiology, University of Michigan, Ann Arbor 48109-0622, USA.
Summary
Growth hormone (GH) triggers cell signaling pathways by binding to its receptor, activating JAK2 kinase. This initiates complex networks regulating gene transcription for growth and metabolism.
Area of Science:
- Endocrinology
- Molecular Biology
- Cell Signaling
Background:
- Growth hormone (GH) exerts varied effects on growth and metabolism through multiple signaling pathways.
- GH initiates intracellular signaling upon binding to the GH receptor (GHR) on target cells.
Purpose of the Study:
- To elucidate the intricate signaling network downstream of GH receptor activation.
- To understand how GH signaling cascades regulate gene transcription.
Main Methods:
- Investigated the interaction between GH and GHR.
- Analyzed the activation of JAK2 tyrosine kinase.
- Examined the downstream signaling pathways including STATs, MAPK, and PI3K.
Main Results:
- GH binding to GHR leads to JAK2 association and tyrosine phosphorylation.
- Activation of STAT, MAPK, and PI3K signaling cascades was observed.
- Evidence suggests cross-talk among these pathways in regulating GH-responsive genes.
Conclusions:
- GH signaling involves a complex network of interconnected pathways.
- This network integrates signals to regulate gene transcription and mediate GH's effects.