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Peroxisome proliferator-activated receptor gamma (PPargamma) as a novel target for prostate cancer
Matthew R Smith1, Philip W Kantoff
1Massachusetts General Hospital, Boston 02114, USA. smith.matthew@mgh.harvard.edu
Investigational New Drugs
|July 9, 2002
Abstract:
Peroxisome proliferator activated receptor-gamma (PPARgamma) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. PPARgamma is expressed at high levels in adipose tissue and plays a central role in adipocyte differentiation. Recent studies have implicated PPARgamma in the pathogenesis of several human malignancies. Here we review the evidence that PPARgamma contributes to prostate carcinogenesis and the potential for PPARgamma as a novel therapeutic target for prostate cancer.