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The menopause transition: an update.
1Division of Reproductive Endocrinology, Albert Einstein College of Medicine, Bronx, New York 10461, USA. glicktoro@aol.com
Human Reproduction Update
|July 9, 2002
Summary
The menopausal transition involves gradual ovarian aging and hormonal shifts, leading to menstrual changes in mid-life. Understanding these changes aids in managing menopausal symptoms effectively.
Area of Science:
- Reproductive Endocrinology
- Epidemiology
- Genetics
Background:
- The menopausal transition is extensively studied, with new research clarifying ovarian follicle attrition.
- Follicle loss occurs throughout reproductive life, typically impacting cycles in women's forties.
- Subtle hormonal changes precede overt cycle disruption, signaling the menopausal transition.
Purpose of the Study:
- To review current knowledge on the menopausal transition.
- To explain the epidemiological and clinical manifestations of ovarian follicle attrition.
- To focus on the clinical management of menopausal symptoms.
Main Methods:
- Review of worldwide cohort studies.
- Analysis of genetic research on ovarian aging.
- Identification of hormonal patterns during the menopausal transition.
Main Results:
- A paradigm for understanding follicle attrition is emerging.
- Ovarian aging and susceptibility to disease are influenced by genetics.
- Hormonal patterns during the menopausal transition are being identified and analyzed for their link to symptoms.
Conclusions:
- The menopausal transition is characterized by predictable physiological changes.
- Understanding these changes is crucial for effective clinical management.
- Lifestyle modifications and hormonal therapies can manage menopausal symptoms.