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Interactions between vagal afferent nerve subtypes mediating cough.

Brendan J Canning1

  • 1Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA. bjc@jhmi.edu

Pulmonary Pharmacology & Therapeutics
|July 9, 2002
PubMed
Summary

The cough reflex is triggered by vagal afferent nerves. Rapidly adapting receptors and bronchopulmonary C-fibres both initiate cough, potentially interacting in the periphery or brainstem.

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Area of Science:

  • Neuroscience
  • Respiratory Physiology

Background:

  • The cough reflex is a vital protective mechanism.
  • Vagal afferent nerves are known initiators of the cough reflex.

Purpose of the Study:

  • To investigate the specific afferent pathways involved in initiating the cough reflex.
  • To explore the roles of rapidly adapting receptors and C-fibres in cough initiation and their potential interactions.

Main Methods:

  • Review of existing literature on neural pathways of the cough reflex.
  • Analysis of physiological criteria for afferent nerve involvement in cough.

Main Results:

  • Rapidly adapting receptors meet all established criteria for subserving the cough reflex.
  • Bronchopulmonary C-fibres can also initiate cough, possibly dependent on rapidly adapting receptor activity.

Related Experiment Videos

  • Interactions between C-fibres and rapidly adapting receptors may occur both peripherally and centrally (brainstem).
  • C-fibre activation has a coincident inhibitory effect on cough, particularly under general anesthesia.

    • Conclusions:

    • Both rapidly adapting receptors and C-fibres play a role in cough reflex initiation.
    • The interplay between these receptor types is crucial for understanding cough mechanisms.
    • Central and peripheral interactions, along with inhibitory effects, modulate cough reflex sensitivity.