Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heart valve replacement surgery: past, present and future.

Albert Starr1, Cindy L Fessler, Gary Grunkemeier

  • 1The Albert Starr Academic Center for Cardiac Surgery, Providence Heart Institute, Portland, Oregon, USA.

Clinical and Experimental Pharmacology & Physiology
|July 9, 2002
PubMed
Summary

This review highlights advancements in valvular surgery, focusing on tissue valve durability and mathematical analysis. Future research aims for more durable tissue valves and anticoagulation-free mechanical options.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional characterisation and pathological significance of variants of <i>MEF2C</i> promoter in tetralogy of Fallot.

Journal of medical genetics·2026
Same author

Genetic variants of ACTC1 gene promoter in pediatric patients with sporadic patent ductus arteriosus and pathological significance.

Pediatric research·2026
Same author

Pathophysiological Significance of Variants of the HAND1 Gene Promoter in Congenital Atrial Septal Defects: A Study in 632 Chinese Subjects.

Human mutation·2026
Same author

Plasma proteomics of extracellular vesicles identifies key proteins correlating to postoperative atrial fibrillation after coronary artery bypass surgery.

Clinical proteomics·2026
Same author

Characteristics of Protein Profiling and Biomarkers in Aortic Regurgitation With Heart Failure.

Journal of the American Heart Association·2026
Same author

LKB1-AMPK Signaling Pathway in Cardiovascular and Other Diseases.

MedComm·2026

Area of Science:

  • Cardiovascular Surgery
  • Biomaterials Science
  • Medical Statistics

Background:

  • Valvular surgery is crucial for treating heart disease, with ongoing advancements in prostheses.
  • Tissue valve durability and patient age at implantation are key factors influencing long-term outcomes.
  • Complications like thrombosis and thromboembolism (TE) remain critical considerations in valve replacement.

Purpose of the Study:

  • To review the historical, current, and future roles of valvular surgery.
  • To analyze the durability of tissue valves using mathematical models.
  • To compare the performance and complication rates of different prosthetic valve types.

Main Methods:

  • Literature review of valvular surgery historical data and current practices.

Related Experiment Videos

  • Mathematical analysis of tissue valve durability using Weibull distribution.
  • Comparative analysis of complication rates (thrombosis, TE) across different valve types.

    • Main Results:

    • The Weibull distribution effectively models tissue valve deterioration.
    • Significant durability differences exist among pericardial valves; Carpentier-Edwards shows superior performance.
    • Patient age at implantation is critical for long-term survival prediction.
    • Thrombosis incidence is low in humans for artificial valves; late TE incidence is ~1.5-2%/year.
    • Tissue valves show reduced thrombosis risk compared to mechanical valves.

    Conclusions:

    • Valvular surgery has significantly improved operative mortality and long-term survival.
    • Glutaraldehyde-preserved pericardial valves demonstrate enhanced durability.
    • While complication rates are similar, tissue valves offer an advantage in reduced thrombosis risk.
    • Continued research is needed for more durable tissue valves and anticoagulation-free mechanical options.