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Ectopic growth hormone-releasing hormone secretion by thymic carcinoid tumour
1Department of Endocrinology, Universitary Hospital of Alicante, University Miguel Hernández, Spain. ev.boixc@coma.es
Clinical Endocrinology
|July 9, 2002
Abstract:
The case of a 33-year-old-woman with Multiple Endocrine Neoplasia Type 1 (MEN1) syndrome and acromegaly due to ectopic growth hormone-releasing hormone (GHRH) secretion by a thymic carcinoid tumour is reported. Immunohistochemistry revealed positive immunoreactivity for GHRH, vasoactive intestinal polypeptide, somatostatin and alpha-subunit in the tumour cells. A previously undescribed new germ line mutation of the MEN1 protein gene was revealed.