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Peripheral T-cell lymphoma with a nodular growth pattern.

Ben Hatano1, Takuya Fukushima, Miyuki Honda

  • 1First Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan.

Pathology International
|July 9, 2002
PubMed
Summary

This study details a rare case of peripheral T-cell lymphoma (PTCL) exhibiting a nodular growth pattern. Recognizing this unusual presentation is crucial for accurate diagnosis and distinguishing it from other lymphoid conditions.

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of aggressive non-Hodgkin lymphomas.
  • Nodular growth patterns are exceptionally rare in PTCL, with limited prior case reports.

Observation:

  • An 81-year-old Japanese woman presented with malaise, fever, and generalized lymphadenopathy.
  • Cervical lymph node biopsy revealed medium- to large-sized atypical lymphoid cells with a distinct nodular growth pattern.
  • Immunohistochemistry confirmed T-helper cell origin (CD4+), and T-cell receptor gamma-chain analysis showed monoclonal rearrangement.

Findings:

  • The case highlights a rare nodular growth pattern in peripheral T-cell lymphoma.
  • Histological and immunohistochemical features confirmed the T-helper cell origin of the atypical lymphoid cells.

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  • Molecular analysis indicated a monoclonal T-cell population, consistent with lymphoma.

    • Implications:

    • Accurate identification of this rare PTCL subtype is essential for appropriate clinical management.
    • Distinguishing this presentation from reactive hyperplasia and other nodular lymphomas is critical.
    • This case expands the understanding of morphological variations within PTCL.