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Cell lineage specification in the nervous system
Gundula Edenfeld1, Jan Pielage, Christian Klämbt
1Institut für Neurobiologie, Universität Münster, Badestr. 9, 48149 Münster, Germany.
Current Opinion in Genetics & Development
|July 9, 2002
Abstract:
Nervous system development requires the specification of numerous neural stem cells. Subsequently these stem cells divide in a spatially and temporally controlled manner to generate the diverse cell types found in the different layers of the nervous system. Lineage specification is brought about by transcriptional regulators, which often act as transcriptional repressors.