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Amphiphilic effects of local anesthetics on rotational mobility in neuronal and model membranes

Il Yun1, Eun-Soo Cho, Hye-Ock Jang

  • 1Department of Dental Pharmacology and Biophysics, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, South Korea. iyun@pusan.ac.kr

Biochimica Et Biophysica Acta
|July 9, 2002
PubMed

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Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
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