Developmental expression of cytochrome CYP26B1 (P450RAI-2) in human cephalic tissues
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Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
Published on: March 28, 2017
Marina E Trofimova-Griffin1, Mont R Juchau
1Department of Pharmacology, School of Medicine, Box 357280, University of Washington, Seattle, WA 98195-7280, USA. griffin3@gte.net
Abstract:
Expression levels of cytochrome CYP26B1, which is involved in the specific all-trans-RA inactivation, were evaluated in human cephalic tissues at gestational days 57-110 and exhibited values approximately 10-fold higher than later gestational days 112-224 and adult tissues. CYP26B1 mRNA levels in the adult cerebellum were approximately 2-fold higher than in the adult whole brain tissue. Considered together, these data suggest a unique role for CYP26B1 during human brain development.

