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17Beta-estradiol stimulates regeneration of sciatic nerve in female mice
Rustem R Islamov1, Wesley A Hendricks, Robert J Jones
1Department of Physiology, The Brody School of Medicine, East Carolina University, 600 Moye Blvd., Greenville, NC 27858, USA.
Abstract:
In ovariectomized mice with and without estrogen replacement, regeneration of the sciatic nerve after crush injury was studied. Functional recovery, quantified with sciatic functional index was significantly accelerated in estrogen-treated mice throughout the regeneration. On semi-thin sections of sciatic nerves in estrogen-treated mice we registered a greater total number of regenerating nerve fibers at the first week, and a higher mean axonal area at the third week of regeneration. Our results demonstrated that estrogen treatment enhances regeneration of the sciatic nerve.