[The carcinogenic action of 1,3-diiminoisoindolin (phthalogen)]

In experiments on mice CC57 and rats (the Rappolovo nursery) the effect of continuous phthalogen injections (from 325 to 467 days) was studied. 36 rats and 99 mice survived the terms of appearance of the first tumors. Average total doses of the drug in subcutaneous injections in the experiments on rats -321-630 mg, while in the experiments on mice - 3,5-5,21 mg, in cutaneous applications - 31 mg per mouse. In the experiments with subcutaneous phthalogen injections tumors arose in 65%, including leucoses - in 54%. These figures exceed nearly twice the corresponding control values. Pulmonary tumors (adenocarcinoma and sarcoma in four cases) were observed at the site of the drug injection. In the experiments on rats sarcomas were found in 9 cases at the site of the injection of the substance. In one rat renal adenocarcinoma developed. The data obtained indicate a weak carcinogenic action of phthalogen.