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Mechanisms of TNF receptor-associated factor (TRAF) regulation in B lymphocytes
Gail A Bishop1, Bruce S Hostager, Kevin D Brown
1Department of Microbiology, 3-570 Bowen Science Building, The University of Iowa, Iowa City, IA 52242, USA. gail-bishop@uiowa.edu
Abstract:
A key component of signaling by members of the tumor necrosis factor receptor (TNF-R) family is interaction with the cytoplasmic adapter proteins known as TRAFs. Several proteins encoded by microbes also interact with TRAFs. A notable example is the CD40 receptor, expressed on antigen presenting cells and providing key activation signals in T cell-dependent B cell activation. CD40 signals to B cells are mimicked by a constitutively active viral protein produced by the Epstein-Barr virus. For each of these receptors, multiple mechanisms of TRAF regulation contribute to signal transduction and the ultimate effect on the B cell. Recent findings concerning these regulatory mechanisms are summarized in this overview.
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