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Updated: Sep 30, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

TMEFF2 is an androgen-regulated gene exhibiting antiproliferative effects in prostate cancer cells

Sigal Gery1, Charles L Sawyers, David B Agus

  • 1Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, California, CA 90048, USA. gerys@schc.org

Oncogene
|July 9, 2002
PubMed

Insights

We discovered TMEFF2, an androgen-regulated gene, suppresses prostate cancer growth. Its decreased expression in advanced cancers may drive more malignant behavior.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Prostate cancer progression is often linked to androgen signaling.
  • Identifying genes regulated by androgens is crucial for understanding cancer development.
  • The TMEFF2 gene's function in prostate cancer was previously unknown.

Purpose of the Study:

  • To investigate the role of the TMEFF2 gene in prostate cancer.
  • To determine if TMEFF2 expression is regulated by androgens.
  • To explore the therapeutic potential of TMEFF2 in prostate cancer.

Main Methods:

  • Gene expression analysis in prostate cancer cell lines and xenografts.
  • Dihydrotestosterone treatment to assess androgen regulation.
  • Xenograft models to study TMEFF2 expression in vivo.
  • Ectopic expression of TMEFF2 in prostate cancer cells.

Main Results:

  • TMEFF2 is highly expressed in androgen-dependent prostate cancer cells and tissues.
  • Androgen stimulation significantly increases TMEFF2 expression.
  • TMEFF2 expression decreases upon castration in xenograft models.
  • Overexpression of TMEFF2 inhibits the growth of prostate cancer cells.
  • Androgen-independent prostate cancer xenografts show lower TMEFF2 mRNA levels.

Conclusions:

  • TMEFF2 is an androgen-regulated gene that acts as a tumor suppressor in prostate cancer.
  • Reduced TMEFF2 expression correlates with the transition to androgen independence and potentially more aggressive cancer.
  • TMEFF2 represents a potential therapeutic target for prostate cancer treatment.

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