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Intrarectal administration of 5-aminosalicylic acid to rabbits and dogs
E L Berryman1, A C Zerouala, C Meschter
1LAB Pre-Clinical Research International Inc., Laval, Quebec, Canada. berrymanl@preclin.com
Abstract:
Intrarectal administration of 5-aminosalicylic acid (5-ASA) to rabbits and dogs was performed to obtain safety data. Groups of rabbits and dogs received twice daily intrarectal doses of 250, 500 or 1000 mg 5-ASA for 14 consecutive days. Treatment had no adverse effect on the behaviour or performance of the animals and microscopic examination revealed no evidence of systemic or local toxicity.
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