[Treatment of hypertension with propranolol in combination with other antihypertensive agents]

In two separated treatment groups of 18 and 30 hypertensive patients of the clinical degrees of severity II and III after insufficient propranolol monotherapy a combined propranolol/hydralazine or propranolol/hydrochlorothiazide treatment, respectively, was performed during several months. Under the combination therapy on average a clear increase of the effect of the beta-receptor blocker on the systolic as well as on the diastolic blood pressure is achieved. There were no essential side-effects. In accordance with modern opinions in the therapy of hypertension the combination of propranolol with a peripheral vasodilator and/or a salidiuretic should find a wide area of use, above all in hypertensive patients who are diastolically more difficult to be stabilised. The production of an adequate combination preparation is to be taken into consideration.