Related Experiment Videos
Linkage analysis of Alzheimer disease with psychosis
S A Bacanu1, B Devlin, K V Chowdari
1Department of Psychiatry, University of Pittsburgh, School of Medicine, PA, USA.
Neurology
|July 10, 2002
Abstract:
Although a portion of risk for late-onset AD (LOAD) is attributable to APOE, the search for other loci is ongoing. The authors hypothesize that psychotic symptoms with LOAD (LOAD+P) identify a potentially more etiologically homogeneous form of AD. Linkage analysis of families with LOAD+P identified one significant and several suggestive novel linkage signals, which bolsters the conjecture of greater etiologic homogeneity.