How do parents perceive high-dose chemotherapy and autologous stem cell transplantation for their children

D Oppenheim1, D Valteau-Couanet, S Vasselon

  • 1Pediatrics Department, and Unit of Psycho-oncology, Institut Gustave Roussy, Villejuif, France.

Insights

Parents undergoing adolescent and child psychiatric treatment (ASCT) experience significant distress and role difficulties. Support from a multidisciplinary team can help families navigate these challenges.

Area of Science:

  • Psychiatry
  • Psychoanalysis
  • Child Psychology

Background:

  • Parental perception of children undergoing treatment is crucial for therapeutic success.
  • Adolescent and Child Psychiatry (ASCT) units often involve complex family dynamics.
  • Understanding parental distress is key to effective child and adolescent mental health care.

Purpose of the Study:

  • To explore parents' perceptions and experiences of their children treated in an ASCT unit.
  • To identify the psychological and social challenges faced by parents during their child's treatment.
  • To understand the parental relationship with care providers and its impact on treatment.

Main Methods:

  • Qualitative study involving semi-structured interviews with 40 parents.
  • Interviews conducted by a psychiatrist-psychoanalyst over a 9-month period.
  • Analysis of parental narratives regarding distress, role difficulties, and relationship dynamics.

Main Results:

  • Parents reported intense distress, helplessness, and guilt.
  • Distorted parent-child relationships and ambivalent connections with care providers were common.
  • Parents experienced disturbed temporal and social landmarks, impacting their sense of continuity and social engagement.

Conclusions:

  • Parents undergoing ASCT treatment experience significant psychological and social disorientation.
  • A psycho-oncology-informed multidisciplinary team can effectively support parents.
  • Interventions should focus on enhancing parental understanding, balancing roles, and preventing familial conflict.

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...