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Updated: Sep 30, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
How do parents perceive high-dose chemotherapy and autologous stem cell transplantation for their children
D Oppenheim1, D Valteau-Couanet, S Vasselon
1Pediatrics Department, and Unit of Psycho-oncology, Institut Gustave Roussy, Villejuif, France.
Insights
Parents undergoing adolescent and child psychiatric treatment (ASCT) experience significant distress and role difficulties. Support from a multidisciplinary team can help families navigate these challenges.
Area of Science:
- Psychiatry
- Psychoanalysis
- Child Psychology
Background:
- Parental perception of children undergoing treatment is crucial for therapeutic success.
- Adolescent and Child Psychiatry (ASCT) units often involve complex family dynamics.
- Understanding parental distress is key to effective child and adolescent mental health care.
Purpose of the Study:
- To explore parents' perceptions and experiences of their children treated in an ASCT unit.
- To identify the psychological and social challenges faced by parents during their child's treatment.
- To understand the parental relationship with care providers and its impact on treatment.
Main Methods:
- Qualitative study involving semi-structured interviews with 40 parents.
- Interviews conducted by a psychiatrist-psychoanalyst over a 9-month period.
- Analysis of parental narratives regarding distress, role difficulties, and relationship dynamics.
Main Results:
- Parents reported intense distress, helplessness, and guilt.
- Distorted parent-child relationships and ambivalent connections with care providers were common.
- Parents experienced disturbed temporal and social landmarks, impacting their sense of continuity and social engagement.
Conclusions:
- Parents undergoing ASCT treatment experience significant psychological and social disorientation.
- A psycho-oncology-informed multidisciplinary team can effectively support parents.
- Interventions should focus on enhancing parental understanding, balancing roles, and preventing familial conflict.
Abstract:
Our objective was to understand the parents' perception of children treated in an ASCT unit. Parents (40) of children and adolescents were interviewed by the department psychiatrist-psychoanalyst, over 9 months. They expressed great distress (22), considerable difficulty in assuming their parental role (with feelings of helplessness and guilt), and had distorted relations with the child whose behavior was unusual and incomprehensible (22). The relation with care providers, who should be 'all-powerful' and harmless, was ambivalent (15). They found it difficult to think or refused to do so, because their 'thoughts are terrifying', and they wanted to forget everything (11). The couple was going through a crisis (9). Temporal landmarks were disturbed (8); ASCT was experienced as a threatening discontinuity in the course of treatment (parents were unable to think of the past, the future, or the present); social landmarks were disturbed (6) with loss of social and professional relations. We concluded that parents may experience intense distress and disorientation. Trained to understand the parents' and their children's thoughts and behavior, the medical team, which includes a psycho-oncologist, can better help them to understand and support the children, to strike a balance between their parental role and other responsibilities, and prevent conflicts.
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