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Horizontal Interactions in Cat Striate Cortex: II. A Current Source-Density Analysis.

H. J. Luhmann1, J. M. Greuel, W. Singer

  • 1Universität Köln, Physiologisches Institut, Albertus-Magnus-Platz, D-5000 Köln 41, FRG.

The European Journal of Neuroscience
|January 1, 1990
PubMed
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Tangential synaptic connections in the visual cortex spread further in kittens than adult cats. Visual experience does not alter this age-dependent spread of neural activity in cats.

Area of Science:

  • Neuroscience
  • Visual Cortex Research
  • Synaptic Plasticity

Background:

  • Understanding the organization of synaptic connections in the primary visual cortex is crucial for comprehending visual processing.
  • Tangential connections play a significant role in integrating information across cortical areas.

Purpose of the Study:

  • To investigate the organization and spatial spread of tangential synaptic connections in the primary visual cortex.
  • To determine the influence of age and visual experience on these connections.

Main Methods:

  • Current Source-Density (CSD) analysis was employed to map field potentials.
  • Intracortical microstimulation was used in normally reared, binocularly deprived, and dark-reared cats and kittens.
  • N-methyl-D-aspartate (NMDA) lesions of the lateral geniculate nucleus excluded thalamo-cortical fiber contamination.

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Main Results:

  • Distinct layer-specific patterns of lateral activity spread were observed.
  • Supragranular layers consistently showed the most prominent and widespread responses.
  • Spatial spread of responses significantly decreased with age but was unaffected by visual deprivation.

Conclusions:

  • Tangential excitatory interactions in the visual cortex decrease in spatial spread with age.
  • The laminar pattern and age-dependent reduction of these interactions are independent of visual experience.
  • These pathways likely involve excitatory synapses on pyramidal cell apical dendrites.