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Cells that Express Brain-Derived Neurotrophic Factor mRNA in the Developing Postnatal Rat Brain
Wilma J. Friedman1, Lars Olson, Håkan Persson
1Departments of Medical Chemistry, Laboratory of Molecular Neurobiology and.
The European Journal of Neuroscience
|July 1, 1991
Summary
Brain-derived neurotrophic factor (BDNF) shows varied expression patterns in the developing rat brain. This study maps BDNF mRNA, revealing transient and persistent expression linked to neuronal maturation.
Area of Science:
- Neuroscience
- Developmental Biology
Background:
- Brain-derived neurotrophic factor (BDNF) is crucial for neuronal survival and growth.
- Understanding BDNF's role in postnatal brain development is essential.
Purpose of the Study:
- To investigate the temporal and spatial expression of BDNF during postnatal brain development.
- To correlate BDNF expression patterns with neuronal maturation.
Main Methods:
- In situ hybridization was used to examine BDNF mRNA expression.
- Analysis focused on various brain regions in developing rats.
Main Results:
- BDNF mRNA expression was observed in specific neocortical regions by 2 weeks of age.
- Transient expression was noted in brainstem structures, while persistent expression occurred in forebrain and hippocampus.
- Hippocampal BDNF levels increased by 2 weeks, with changes in dentate gyrus labeling over time.
- A caudal to rostral gradient of BDNF expression was suggested.
Conclusions:
- BDNF exhibits both transient and persistent expression patterns during postnatal development.
- These patterns suggest a role for BDNF in neuronal maturation and development.
- Findings indicate a caudal to rostral gradient of BDNF expression correlating with neuronal maturation.