Related Experiment Videos
Stimulation of B lymphocytes, macrophages, and dendritic cells by protozoan DNA
Wendy C Brown1, Ricardo S Corral
1Program in Vector-Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USA. wbrown@vetmed.wsu.edu
Microbes and Infection
|July 11, 2002
Abstract:
This review summarizes recent work from our laboratory demonstrating the activation of B lymphocytes, macrophages and dendritic cells by DNA from three different protozoan parasites of cattle and humans that is qualitatively similar to the now well-described effects of CpG-containing bacterial DNA. This novel mechanism of protozoan parasite recognition by the innate immune system could facilitate recovery from acute infection or contribute to infection-related pathology.