Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acetylcysteine and contrast agent-associated nephrotoxicity.

Carlo Briguori1, Fiore Manganelli, Pierfranco Scarpato

  • 1Laboratory of Interventional Cardiology and Department of Cardiology, Clinica Mediterranea, Via Orazio 2, I-80121 Naples, Italy. cabrig@hotmail.com

Journal of the American College of Cardiology
|July 11, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Newly available and recent advances in drug-eluting stents.

Expert review of cardiovascular therapy·2013
Same author

Reply: To PMID 23257375.

JACC. Cardiovascular interventions·2013
Same author

Can bioabsorbable scaffolds be used in calcified lesions?

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2013
Same author

Impact of residual chronic total occlusion of right coronary artery on the long-term outcome in patients treated for unprotected left main disease: the Milan and New-Tokyo registry.

Circulation. Cardiovascular interventions·2013
Same author

[Intra-arterial thrombolysis facilitated by ultrasound in submassive pulmonary embolism: first documented case report in Italy].

Giornale italiano di cardiologia (2006)·2013
Same author

Renal denervation in a patient with two renal accessory arteries: a case report.

Blood pressure·2013

Prophylactic acetylcysteine with hydration may help prevent contrast-induced kidney injury, especially with low contrast doses. However, the total contrast amount was the main predictor of nephrotoxicity in this study.

Area of Science:

  • Nephrology
  • Radiology
  • Pharmacology

Background:

  • Contrast media administration can precipitate acute kidney injury (AKI), sometimes necessitating dialysis.
  • Patients with pre-existing renal impairment are at higher risk for contrast-induced nephropathy (CIN).

Purpose of the Study:

  • To evaluate the efficacy of prophylactic acetylcysteine (N-acetylcysteine) combined with hydration versus hydration alone in preventing CIN.
  • To identify predictors of CIN in patients undergoing angiography.

Main Methods:

  • A randomized controlled trial involving 183 patients with renal impairment undergoing angiography.
  • Patients received either intravenous saline with oral acetylcysteine or intravenous saline alone before and after contrast dye administration.
  • Renal function was assessed by serum creatinine levels 48 hours post-procedure.

Related Experiment Videos

Main Results:

  • No significant difference in overall CIN rates between the acetylcysteine and control groups (6.5% vs. 11%).
  • However, in the subgroup receiving a low contrast dose (<140 ml), acetylcysteine significantly reduced CIN (0% vs. 8.5%, p=0.02).
  • Multivariate analysis identified the volume of contrast agent, not acetylcysteine, as a significant predictor of CIN (OR 2.58).

Conclusions:

  • Prophylactic acetylcysteine did not significantly reduce overall CIN rates in patients with renal impairment.
  • The amount of contrast agent administered was the primary predictor of contrast-induced nephrotoxicity.
  • Acetylcysteine may offer a protective benefit in patients receiving low contrast volumes.