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Age and gender effects on serotonin-dependent plasticity in respiratory motor control
M Behan1, A G Zabka, G S Mitchell
1Department of Comparative Biosciences, School of Veterinary Medicine, 2015 Linden Drive, University of Wisconsin, Madison, WI 53706, USA. behanm@svm.vetmed.wisc.edu
Respiratory Physiology & Neurobiology
|July 11, 2002
Abstract:
We review recent evidence indicating that serotonin-dependent plasticity in respiratory control is influenced by age and gender. Specifically, respiratory long-term-facilitation following intermittent hypoxia decreases with age in male rats, but increases in female rats. We speculate about a possible relationship between age and gender effects on serotonin-dependent plasticity in upper airway motoneuron pools and the prevalence of obstructive sleep apnea.