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Related Experiment Videos

Peripheral vascular structure and function in men with contrasting GH levels.

R John Irving1, Maggie N Carson, David J Webb

  • 1University of Edinburgh, Department of Medical Sciences, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK.

The Journal of Clinical Endocrinology and Metabolism
|July 11, 2002
PubMed
Summary

Growth hormone (GH) deficiency and excess impact cardiovascular health. GH replacement therapy improved arterial stiffness and dermal capillary perfusion in GH-deficient men, suggesting modest direct vascular effects.

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Area of Science:

  • Endocrinology
  • Cardiovascular Physiology
  • Vascular Biology

Background:

  • Growth hormone (GH) deficiency and excess are linked to cardiovascular disease, but direct vascular mechanisms remain unclear.
  • Previous research suggests GH influences endothelium-dependent vasodilation and large artery structure.

Purpose of the Study:

  • To comprehensively assess large artery and microvascular structure and function in individuals with varying GH levels.
  • To investigate the direct vascular effects of GH deficiency and excess in men.

Main Methods:

  • Studied healthy controls, men with acromegaly, and men with adult-onset GH deficiency.
  • Measured arterial wall thickness, stiffness, microvascular flow, dermal capillary density, and endothelial function.
  • Assessed cardiac output in GH-deficient patients and controls.

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Main Results:

  • GH-deficient patients showed trends toward increased arterial wall thickness and stiffness compared to controls.
  • GH replacement therapy significantly reduced arterial stiffness and increased dermal capillary perfusion.
  • No significant differences in forearm/dermal flow or endothelial function were observed between groups or with GH therapy.

Conclusions:

  • Direct vascular effects of GH excess and deficiency in humans are modest.
  • These direct vascular effects may not warrant the highest priority when assessing cardiovascular risks in pituitary disease patients.