Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central mechanisms involved with catabolism.

Jyotirmoy Nandi1, Michael M Meguid, Akio Inui

  • 1Department of Medicine, Gastroenterology Division, University Hospital, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

Current Opinion in Clinical Nutrition and Metabolic Care
|July 11, 2002
PubMed
Summary

Stress triggers brain-initiated catabolism, leading to anorexia and muscle breakdown. This review explores the central neurohormonal pathways driving these metabolic changes and weight loss.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cinnamaldehyde, a major bioactive component of cinnamon bark, enhances social approach behavior associated with a liver-brain FGF21-isotocin axis in zebrafish.

Food & function·2026
Same author

Ninjin'yoeito Kampo medicine enhances zebrafish endurance under forced-swimming conditions via muscle hypertrophy.

Journal of natural medicines·2026
Same author

An Unusual Case of a Central Pontine Myelinolysis Associated with Primary Splenic Diffuse Large B-cell Lymphoma.

Internal medicine (Tokyo, Japan)·2024
Same author

Comparison between single-muscle evaluation and cross-sectional area muscle evaluation for predicting the prognosis in patients with oral squamous cell carcinoma: a retrospective cohort study.

Frontiers in oncology·2024
Same author

Relationship between the severity of pre-frailty and the degree of adaptation of Ninjin'yoeito (NYT) on pre-frailty.

Frontiers in aging·2024
Same author

First Case of COVID-19-Related Left Ventricular Calcification.

Circulation journal : official journal of the Japanese Circulation Society·2024

Area of Science:

  • Neuroendocrinology
  • Metabolic Regulation
  • Stress Response

Background:

  • Catabolism is traditionally viewed as a response to nutrient deprivation.
  • Emerging evidence suggests catabolism is a primary brain-initiated event.
  • Stressors trigger central mechanisms that inhibit feeding and promote tissue breakdown.

Purpose of the Study:

  • To review the central neurohormonal mechanisms underlying stress-induced catabolism.
  • To elucidate the pathways leading to anorexia and weight loss.
  • To summarize recent progress in understanding central anorexia and weight loss.

Main Methods:

  • Review of neurohormonal mediators in the central nervous system.
  • Analysis of the hypothalamic-pituitary-adrenal axis and autonomic nervous system.

Related Experiment Videos

  • Examination of counter-regulatory hormone stimulation and anabolic hormone inhibition.

    • Main Results:

    • Stress activates central pathways involving corticotropin-releasing factor and serotonin.
    • Neurohormonal cascades stimulate catecholamines, cortisol, and counter-regulatory hormones.
    • Anabolic hormones, including insulin and leptin, are inhibited, leading to anorexia and weight loss.

    Conclusions:

    • Stress-induced anorexia and catabolism are centrally regulated neuroendocrine events.
    • These processes mobilize metabolic fuels via gluconeogenesis, glycogenolysis, and ketogenesis.
    • Understanding these central mechanisms is crucial for addressing conditions like cachexia.