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Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity
Published on: August 19, 2013
Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum
N P Lees1, K L Harrison, E Hill
1Cancer Research UK, Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester M20 9BX, UK.
British Journal of Cancer
|July 11, 2002
Abstract:
In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis.
