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[Periodic fevers].

F Hayem1

  • 1Service de pédiatrie générale, hôpital Necker-Enfants-Malades, 149, rue de Sèvres, 75743 Paris, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|July 11, 2002
PubMed
Summary
This summary is machine-generated.

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Periodic fever involves recurrent unexplained fevers, often starting in childhood, with associated symptoms. Four causes are known, including hereditary and sporadic types, but many cases remain undiagnosed.

Area of Science:

  • Pediatric rheumatology
  • Immunology
  • Genetics

Context:

  • Periodic fever syndromes are characterized by recurrent febrile episodes.
  • These episodes are often accompanied by systemic inflammatory manifestations.
  • Onset typically occurs in childhood, with asymptomatic intervals between flares.

Purpose:

  • To define periodic fever and outline its known etiologies.
  • To differentiate between hereditary and sporadic forms of periodic fever.
  • To highlight the existence of unexplained cases.

Summary:

  • Periodic fever presents as recurrent, self-limiting febrile episodes, usually in childhood.
  • Clinical features include inflammation of serous membranes, joints, skin, and mucous membranes.

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  • Known causes include Familial Mediterranean Fever, Hyperimmunoglobulinemia D with Recurrent Fever, TNF Receptor Associated Periodic Syndrome (TRAPS), and PFAPA.

    • Impact:

    • Clarifies the diagnostic criteria and known causes of periodic fever syndromes.
    • Emphasizes the need for further research into unidentified etiologies.
    • Provides a foundation for understanding and managing these rare inflammatory conditions.