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Updated: Sep 30, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
Effects of amidine derivatives on parasite-macrophage interaction and evaluation of toxicity
Rosane M Temporal1, Léa Cysne-Finkelstein, Aurea Echevarria
1Department of Immunology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
Abstract:
In this work, the effect of amidine derivatives (with bromine and methoxy as substituents) in the "in vitro" parasite-macrophage interaction was evaluated. The potential toxicity was also analyzed. The results show that the methoxy-derivative was able to decrease the percentage of "in vitro" infection, being not hazardous to the host cell. Furthermore, experiments using Balb/c mice showed that this compound was very effective in avoiding infection in these animals. On the other hand, the compound with bromine as substituent was toxic to macrophages and unable to prevent infection in Balb/c mice. Pentamidine isethionate, used as reference drug, was not efficient in both experiments.
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