Pathological and clinical aspects of the diseases caused by Malassezia species

J Dorogi1

  • 1Dr. Juhász Tamás Clinic for Small Animals, Ecseri út 6, H-1098 Budapest, Hungary.

Insights

Malassezia pachydermatis is a significant yeast in veterinary medicine, frequently causing skin and ear infections in dogs. While common on healthy animals, it increases in diseased dogs and can affect other carnivores.

Area of Science:

  • Veterinary Dermatology
  • Microbiology
  • Mycology

Background:

  • Malassezia pachydermatis is a yeast of significant veterinary importance, particularly in canine dermatology.
  • It is frequently implicated in cases of otitis externa and dermatitis in dogs.
  • This yeast is lipid-independent and commonly found on the skin of healthy animals, but at higher concentrations in diseased individuals.

Purpose of the Study:

  • To review the veterinary significance of Malassezia pachydermatis.
  • To discuss its role in canine and other carnivore skin disorders.
  • To highlight its etiological role, predisposing factors, and treatment approaches.

Main Methods:

  • Literature review focusing on veterinary studies concerning Malassezia pachydermatis.
  • Analysis of its prevalence in healthy versus diseased animals.
  • Examination of co-infections and therapeutic strategies.

Main Results:

  • Malassezia pachydermatis is a primary cause of otitis externa and dermatitis in dogs, often in conjunction with other pathogens.
  • Certain dog breeds exhibit predispositions to Malassezia-related skin conditions.
  • Therapeutic interventions commonly include systemic and topical antimicrobial treatments, with ketoconazole being frequently used.

Conclusions:

  • Malassezia pachydermatis is a key pathogen in veterinary dermatology, especially for dogs.
  • While it has low zoonotic potential, it can pose risks to immunocompromised humans.
  • Other Malassezia species have limited veterinary significance, though some have been isolated from animals.

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...