Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrocardiogram with prolonged QT interval in Gitelman disease.

Alberto Bettinelli1, Camillo Tosetto, Giacomo Colussi

  • 1Pediatric Renal Unit, University of Milan Medical School, Clinica De Marchi, Milan, Italy.

Kidney International
|July 12, 2002
PubMed
Summary

Gitelman disease patients often have a prolonged QT interval, increasing their risk for dangerous cardiac arrhythmias. This study assessed QT intervals in Gitelman disease patients, revealing a significant prevalence of prolonged intervals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cord blood-derived mesenchymal stromal cells in children with steroid-dependent nephrotic syndrome: a prospective phase II study.

Clinical kidney journal·2026
Same author

Electrolyte balance and muscle damage after adolescent binge alcohol use: a retrospective study.

Italian journal of pediatrics·2026
Same author

Kidney calcifications and fluid-electrolyte imbalances in cystic fibrosis: a simplified synopsis.

Pediatric nephrology (Berlin, Germany)·2026
Same author

Intraperitoneal pressure measurements in children on peritoneal dialysis: a review and European practice survey.

Pediatric nephrology (Berlin, Germany)·2026
Same author

Hospital readmission in children on maintenance dialysis: a multicentre, prospective cohort study.

Clinical kidney journal·2026
Same author

Exercise-Induced Purpura: Systematic Review of the Literature.

Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine·2026

Area of Science:

  • Cardiology
  • Genetics
  • Electrophysiology

Background:

  • Potassium and magnesium deficiencies are known to prolong the QT interval and increase the risk of cardiac arrhythmias.
  • Gitelman disease is a genetic disorder affecting renal salt reabsorption, but its impact on cardiac repolarization remains unstudied.

Purpose of the Study:

  • To investigate the QT interval duration in patients diagnosed with Gitelman disease.
  • To determine if Gitelman disease is associated with prolonged QT intervals and an increased risk of arrhythmias.

Main Methods:

  • Assessed the corrected QT interval using the Bazett formula in 27 genetically and biochemically confirmed Gitelman disease patients after a four-week treatment cessation.
  • Analyzed demographic data, plasma electrolytes (potassium, magnesium, calcium, sodium, chloride), and bicarbonate levels in relation to QT interval duration.

Related Experiment Videos

Main Results:

  • The corrected QT interval was prolonged in 11 out of 27 (40.7%) Gitelman disease patients.
  • Patients with prolonged QT intervals showed significantly lower plasma sodium and chloride levels and higher bicarbonate levels compared to those with normal QT intervals.
  • No significant differences were observed in gender ratio, plasma potassium, magnesium, or ionized calcium between groups.

Conclusions:

  • A significant proportion of Gitelman disease patients exhibit a pathologically prolonged corrected QT interval.
  • This finding suggests an elevated risk for dangerous cardiac arrhythmias in Gitelman disease patients.
  • Further research is warranted to precisely evaluate the arrhythmia hazard in Gitelman disease patients with prolonged QT intervals.