Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue engineering: chondrocytes and cartilage.

Tim Hardingham1, Simon Tew, Alan Murdoch

  • 1UK Centre for Tissue Engineering, School of Biological Sciences, University of Manchester, UK. tim.hardingham@ukcte.org

Arthritis Research
|July 12, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design, synthesis and biological activity of glycoconjugated ADAMTS5 exosite inhibitors: applications in osteoarthritis and ovarian cancer models.

Scientific reports·2025
Same author

Editorial: Epigenetic regulation of the musculoskeletal system in health, disease, and aging.

Frontiers in endocrinology·2023
Same author

Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations.

Cells·2022
Same author

Extending the Paradigm of Osteoarthritis: Comment on the Editorial by McAlindon.

Arthritis & rheumatology (Hoboken, N.J.)·2015
Same author

Magnetic resonance compositional imaging of articular cartilage: What can we expect in veterinary medicine?

Veterinary journal (London, England : 1997)·2015
Same author

Cell- and tissue-based approaches for cartilage repair.

Alternatives to laboratory animals : ATLA·2011
Same journal

21st European workshop for rheumatology research.

Arthritis research·2014
Same journal

21st European Workshop for Rheumatology Research, Vienna, Austria, 1-4 March 2001. Abstracts.

Arthritis research·2005
Same journal

Effects of disease modifying agents and dietary intervention on insulin resistance and dyslipidemia in inflammatory arthritis: a pilot study.

Arthritis research·2002
Same journal

Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers.

Arthritis research·2002
Same journal

VLA-4-dependent and -independent pathways in cell contact-induced proinflammatory cytokine production by synovial nurse-like cells from rheumatoid arthritis patients.

Arthritis research·2002
Same journal

Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren's syndrome.

Arthritis research·2002
See all related articles

Tissue engineering uses cell biology to develop treatments for tissue repair, focusing initially on cartilage regeneration for arthritis. These strategies aim to restore function in damaged musculoskeletal tissues like bone, ligament, and tendon.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cell Biology

Background:

  • Arthritic diseases significantly impact quality of life, necessitating novel therapeutic strategies.
  • Tissue engineering offers promising approaches for repairing and regenerating damaged or diseased tissues.
  • Understanding cell biology principles is crucial for directing cell function in regenerative treatments.

Purpose of the Study:

  • To explore tissue engineering strategies for treating arthritic diseases.
  • To investigate cartilage repair using cell-based approaches.
  • To elucidate signals that promote chondrocyte-mediated matrix assembly.

Main Methods:

  • Utilizing principles of cell biology to guide tissue regeneration.
  • Focusing on chondrocytes and their role in cartilage matrix production.

Related Experiment Videos

  • Developing strategies for musculoskeletal tissue repair.

    • Main Results:

    • Initial research focuses on cartilage repair mechanisms.
    • Identifying key signals required for chondrocytes to assemble new matrix.
    • Laying groundwork for broader musculoskeletal tissue applications.

    Conclusions:

    • Tissue engineering holds potential for treating degenerative diseases like arthritis.
    • Elucidating cellular signals is key to advancing cartilage repair.
    • The principles developed will be applicable to bone, ligament, and tendon regeneration.