Toxicogenomics: a new revolution in drug safety
Related Experiment Video
Updated: Sep 30, 2026

Cost-Efficient Transcriptomic-Based Drug Screening
Published on: February 23, 2024
Arthur L Castle1, Michael P Carver, Donna L Mendrick
1Gene Logic, Gaithersburg, MD, USA.
Abstract:
New drugs are screened for adverse reactions using a laborious, costly process and still some promising therapeutics are withdrawn from the marketplace because of unforeseen human toxicity. Novel higher throughput methods in toxicology need to be developed. These new approaches should provide more insight into potential human toxicity than current methods. Toxicogenomics, the examination of changes in gene expression following exposure to a toxicant, offers the potential to identify a human toxicant earlier in drug development and to detect human-specific toxicants that cause no adverse reaction in rats.
Related Concept Videos
Pharmacogenomics: Identification of New Drug Targets
Pharmacogenetics and Pharmacogenomics: Overview
Pharmacogenetics of Drug Metabolism: Overview
Toxicokinetics: Overview
Drug Toxicity: Dose-Dependent Reactions
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
