Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

K(ATP) channels and insulin secretion disorders.

H Huopio1, S-L Shyng, T Otonkoski

  • 1Department of Pediatrics, Kuopio University Hospital, Kuopio 70211, Finland.

American Journal of Physiology. Endocrinology and Metabolism
|July 12, 2002
PubMed
Summary

Persistent hyperinsulinemic hypoglycemia (HI) is a genetic disorder caused by mutations in K(ATP) channel genes. Understanding these mutations is key to treating HI and controlling insulin secretion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of alcohol on the transcriptome, methylome and metabolome of in vitro gastrulating human embryonic cells.

Disease models & mechanisms·2025
Same author

Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders.

BMC medicine·2022
Same author

Macrophage secretion of miR-106b-5p causes renin-dependent hypertension.

Nature communications·2020
Same author

Anti-Müllerian hormone and letrozole levels in boys with constitutional delay of growth and puberty treated with letrozole or testosterone.

Human reproduction (Oxford, England)·2020
Same author

Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI).

Regenerative medicine·2015
Same author

Congenital hyperinsulinism, neonatal diabetes and the risk of malignancies: an international collaborative study. Preliminary communication.

Diabetic medicine : a journal of the British Diabetic Association·2014

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • ATP-sensitive potassium (K(ATP)) channels regulate insulin secretion in beta-cells.
  • Nutrient oxidation alters ATP-to-ADP ratios, affecting K(ATP) channel activity and insulin release.
  • Persistent hyperinsulinemic hypoglycemia (HI) is a rare genetic disorder of dysregulated insulin secretion.

Purpose of the Study:

  • To review the link between K(ATP) channel activity and defective insulin release in HI.
  • To explore the molecular genetics of HI and its causal mutations.
  • To discuss implications for understanding insulin secretion control in health and disease.

Main Methods:

  • Review of studies on K(ATP) channel function.
  • Analysis of molecular genetics of HI.

Related Experiment Videos

  • Examination of mutations in SUR1 and Kir6.2 genes.

    • Main Results:

    • Mutations in SUR1 and Kir6.2 genes are found in most genetically identified HI cases.
    • These mutations disrupt K(ATP) channel function, leading to dysregulated insulin secretion.
    • Understanding the channel's role is crucial for HI pathogenesis.

    Conclusions:

    • K(ATP) channel dysfunction is central to persistent hyperinsulinemic hypoglycemia.
    • Molecular genetics has significantly advanced the understanding of HI.
    • Further research on K(ATP) channels will illuminate insulin secretion control mechanisms.