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Related Concept Videos

Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

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Electroporation-mediated RNA Interference Method in Odonata
13:28

Electroporation-mediated RNA Interference Method in Odonata

Published on: February 6, 2021

RNA interference.

Gregory J Hannon1

  • 1Cold Spring Harbour Laboratory, New York 11724, USA. hannon@cshl.org

Nature
|July 12, 2002
PubMed
Summary
This summary is machine-generated.

RNA interference (RNAi) is a natural defense against harmful nucleic acids that also regulates gene expression. This conserved biological process is now a powerful tool for experimental gene manipulation and whole-genome function studies.

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Last Updated: Jun 18, 2026

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • A conserved biological pathway, RNA interference (RNAi), also known as post-transcriptional gene silencing, plays a crucial role in cellular defense mechanisms.
  • This process targets both endogenous parasitic and exogenous pathogenic nucleic acids, providing a fundamental layer of genetic protection.
  • RNAi is integral to the regulation of protein-coding gene expression within eukaryotic cells.

Purpose of the Study:

  • To highlight the dual role of RNA interference (RNAi) as both a natural defense mechanism and a tool for scientific inquiry.
  • To underscore the significance of RNAi in mediating resistance to nucleic acid threats and regulating gene expression.
  • To present RNAi as a cultivated method for experimental gene manipulation and large-scale functional genomics.

Main Methods:

  • The study focuses on the biological mechanisms of RNA interference (RNAi).
  • It examines the role of double-stranded RNA (dsRNA) in triggering this conserved response.
  • The application of RNAi for experimental gene manipulation and functional genomics is discussed.

Main Results:

  • RNA interference (RNAi) effectively mediates resistance against parasitic and pathogenic nucleic acids.
  • RNAi plays a critical role in the post-transcriptional regulation of protein-coding genes.
  • The process has been successfully adapted for experimental manipulation of gene expression.

Conclusions:

  • RNA interference (RNAi) is a fundamental biological process with significant implications for both innate immunity and gene regulation.
  • Its utility has been harnessed for advanced research, enabling precise control over gene expression.
  • RNAi serves as a valuable tool for exploring gene function across the entire genome.