Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Isolated amoebic appendicitis.

P K Ramdial1, T E Madiba, S Kharwa

  • 1Department of Anatomical Pathology, Nelson R. Mandela School of Medicine, Faculty of Health Sciences, University of Natal, Private Bag 7, Congella 4013, Kwazulu Natal, South Africa. ramdial@nu.ac.za

Virchows Archiv : an International Journal of Pathology
|July 12, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Alport variant illuminates the bioactivity of the collagen IV <sup>α565- α121</sup> scaffold in Bowman's capsule.

bioRxiv : the preprint server for biology·2026
Same author

Clinicopathological spectrum and outcome of appendicectomy at a South African tertiary hospital: continuing impact of delayed presentation.

African health sciences·2025
Same author

Combining phenotypic and genomic data to improve prediction of binary traits.

Journal of applied statistics·2024
Same author

Predicting gallstone pancreatitis in HIV infected patients.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2024
Same author

The clinicopathological spectrum and treatment outcomes in metastatic colorectal cancer in the KwaZulu-Natal province of South Africa.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2023
Same author

A South African central hospital's experience with malignant colorectal obstruction.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2023

Isolated amoebic appendicitis (IAA) is a rare condition often mistaken for bacterial appendicitis. Prompt diagnosis via histopathology and treatment with metronidazole are crucial for survival, as evidenced by this 9-year study.

Area of Science:

  • Tropical medicine
  • Gastroenterology
  • Pathology

Background:

  • Amoebiasis is a widespread disease, particularly in areas with poor sanitation.
  • Isolated amoebic appendicitis (IAA) is an uncommon presentation of amoebiasis.
  • Distinguishing IAA from bacterial appendicitis clinically is challenging, necessitating histopathological diagnosis.

Purpose of the Study:

  • To investigate the clinicopathological features of isolated amoebic appendicitis.
  • To evaluate the diagnostic and management strategies for IAA.
  • To highlight the importance of timely intervention in IAA cases.

Main Methods:

  • A 9-year retrospective study of patients diagnosed with IAA.
  • Analysis of clinical presentations, intra-operative findings, and gross pathological appraisals.

Related Experiment Videos

  • Detailed histopathological examination of appendices, including vascular pathology assessment.
  • Review of treatment outcomes, focusing on metronidazole therapy and appendicectomy.

    • Main Results:

    • Fever and abdominal pain were the primary symptoms; dysentery was absent.
    • Pre-operative and intra-operative diagnoses were predominantly acute appendicitis.
    • Histopathology confirmed appendiceal ulceration, inflammation, amoebic trophozoites, and necrosis in all cases.
    • Vascular pathologies, including vasculitis and thrombophlebitis, were observed in a significant number of cases.
    • 18 patients treated with metronidazole survived, while 3 untreated patients died.

    Conclusions:

    • Appendicectomy and accurate histopathological examination are vital for diagnosing IAA.
    • Timely management with metronidazole significantly improves patient outcomes.
    • IAA requires specific diagnostic and therapeutic considerations distinct from bacterial appendicitis.