Primary liposarcoma of bone

A case is presented of a rare primary liposarcoma of bone localized to the major trochanter of the left femur of a 52-year-old female. Despite combined treatment with curettage and irradiation with a total dose of 4,500 rad the neoplasm showed rapid invasive growth with destruction of the bone, spread to the iliac fossa and outgrowth through the operation wound. Approximately 5 months after admission the patient succumbed due to widespread metastases in the lungs, liver and left kidney. The histopathology, clinical course and treatment of this rare neoplasm of the bone are discussed.