Web-based detection of genotype errors in pedigree data
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Updated: Sep 30, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
Published on: August 15, 2019
Masayuki Saito1, Akira Saito, Naoyuki Kamatani
1Division of Statistical Genetics, Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan. msaito@ior.twmu.ac.jp
Abstract:
For linkage analysis using pedigree data, it is important to eliminate contradictions concerning Mendelian inheritance from genotypic data. Such contradictions may derive from either genotyping errors or pedigree errors. We implemented an error-checking algorithm in a World Wide Web-based program that can be used through the Internet even by computer nonspecialists. This program, named Checkfam, uses two error-checking algorithms to detect and report contradictions concerning Mendelian inheritance. With this program, users can guess the causes of genotype errors (technical problems in genotyping, pedigree misrecording, or errors in input data concerning familial relationships). The present program will be useful to researchers for checking genotypic data and for preparing correct input files for linkage analysis.
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