Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Suprachiasmatic nucleus organization.

Robert Y Moore1, Joan C Speh, Rehana K Leak

  • 1Department of Neurology, University of Pittsburgh, 3471 Fifth Ave., Suite 811, Pittsburgh, PA 15213, USA.

Cell and Tissue Research
|July 12, 2002
PubMed
Summary

The suprachiasmatic nucleus (SCN) in rats has distinct core and shell regions. This study quantitatively analyzes their organization and functional significance in circadian rhythm control.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adiponectin Fortifies White Matter After Chronic Hypoperfusion-Induced Vascular Dementia.

Stroke·2026
Same author

Caloric restriction decelerates premature aging and cognitive decline in mice with deficient DNA repair.

Communications biology·2026
Same author

Single-cell transcriptomic analyses reveal angiogenic vascular responses to chronic cerebral hypoperfusion.

iScience·2026
Same author

Galectin-3 mediates lysosome-related inflammation within monocyte-derived macrophages in a mouse model of ischemic brain injury.

The Journal of clinical investigation·2026
Same author

Testing an inverse link between limbic alpha-synucleinopathy and myelin markers in mice and humans.

NPJ Parkinson's disease·2026
Same author

Monocyte-derived macrophages and their roles in ischemic stroke.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026

Area of Science:

  • Neuroscience
  • Chronobiology
  • Neuroanatomy

Background:

  • The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals.
  • It regulates rest-activity cycles and physiological functions.
  • The SCN has two main subdivisions: the core and the shell.

Purpose of the Study:

  • To quantitatively analyze the organization of the SCN core and shell in rats.
  • To understand the functional significance of these subdivisions in circadian control.

Main Methods:

  • Detailed quantitative analysis of SCN subdivisions in rat brain.
  • Histological and immunocytochemical techniques to identify neuronal populations and connections.

Main Results:

  • The SCN core contains vasoactive intestinal polypeptide (VIP) and gastrin-releasing peptide (GRP) neurons.
  • The SCN shell features arginine vasopressin (AVP) and calretinin (CAR) neurons.
  • Distinct afferent inputs target the core (visual, midbrain raphe) and shell (cortical, subcortical).

Conclusions:

  • The SCN's core and shell exhibit unique cellular compositions and connectivity.
  • These structural differences likely underpin their specific roles in circadian regulation.
  • Understanding SCN organization is crucial for deciphering circadian control mechanisms.

Related Experiment Videos