Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does PTH have a direct effect on intestine?

I Nemere1, D Larsson

  • 1Department of Nutrition and Food Sciences and the Biotechnology Center Utah State University, Logan, Utah 84322-8700, USA. nemere@cc.usu.edu

Journal of Cellular Biochemistry
|July 12, 2002
PubMed
Summary

Parathyroid hormone (PTH) directly influences calcium and phosphate absorption in the intestine, challenging the long-held belief that its effects are solely mediated by vitamin D. This finding has significant implications for understanding mineral metabolism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shear wave elastography plaque characterization with mechanical testing validation: a phantom study.

Physics in medicine and biology·2015
Same author

The ins and outs of phosphate homeostasis.

Kidney international·2007
Same author

The ERp57/GRp58/1,25D3-MARRS receptor: multiple functional roles in diverse cell systems.

Current medicinal chemistry·2007
Same author

Phosphate uptake in chick kidney cells: effects of 1,25(OH)2D3 and 24,25(OH)2D3.

Steroids·2006
Same author

Regulation of parathyroid hypertensive factor secretion by vitamin D3 analogs in parathyroid cells derived from spontaneously hypertensive rats.

Journal of cellular biochemistry·2005
Same author

Receptors for steroid hormones: membrane-associated and nuclear forms.

Cellular and molecular life sciences : CMLS·2004

Area of Science:

  • Endocrinology
  • Gastroenterology
  • Mineral Metabolism

Background:

  • Established dogma posits parathyroid hormone (PTH) indirectly affects intestinal calcium and phosphate absorption via vitamin D synthesis.
  • Emerging evidence suggests a potential direct role for PTH in intestinal mineral absorption.

Purpose of the Study:

  • To review evidence supporting a direct effect of PTH on the intestine.
  • To explore biological and biochemical evidence, as well as intestinal PTH receptors.

Main Methods:

  • Literature review of studies investigating PTH's intestinal effects.
  • Analysis of data on biological and biochemical responses.
  • Examination of evidence for intestinal PTH receptor presence.

Main Results:

Related Experiment Videos

  • Evidence suggests PTH has direct biological and biochemical effects on the intestine.
  • Intestinal receptors for PTH have been identified, supporting a direct interaction.

Conclusions:

  • The traditional view of PTH's indirect intestinal action needs re-evaluation.
  • Direct PTH effects on the intestine have significant implications for biomedical research and mineral metabolism.
  • Further research is warranted to fully elucidate the mechanisms and consequences of direct intestinal PTH signaling.